Linked Life Data

19654439

Source:http://linkedlifedata.com/resource/pubmed/id/19654439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-8-5
pubmed:abstractText
The WBN/Kob rat strain is a hereditary animal model of chronic pancreatitis and diabetes mellitus. The major WBN/Kob loci for pancreatitis (Pdwk1 and Pdwk2) are located on chromosomes 7 and X, respectively. In this study, polymorphisms were sought for candidate genes in the Pdwk1 and Pdwk2 regions. Nucleotide polymorphisms were found in 14 candidate genes examined in the Pdwk1 region. These polymorphisms were not associated with functional changes, and hence were unlikely to be a cause of pancreatitis. Seven nucleotide polymorphisms in three candidate genes, Rac2, Grap2, and Xpnpep3, located within a 3.3-Mb region were not found in 14 other inbred rat strains. These results suggest that WBN/Kob has a unique haplotype block in the chromosomal region contatining Pdwk1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1881-7122
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on chromosome 7.
pubmed:affiliation
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't