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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2009-10-2
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pubmed:databankReference |
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pubmed:abstractText |
The polymorphic products of major histocompatibility complex class I-related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was significantly associated with mismatch at HLA-B and HLA-C. A higher rate of grade II-IV aGVHD was seen in MICA-mismatched patients (80% vs 40%, P = .003) irrespective of degree of HLA matching (HLA 10/10 match: 75% vs 39%, P = .02) and HLA any mismatch (83% vs 46%, P = .003). The rate of grade II-IV gastrointestinal aGVHD was also higher in MICA-mismatched patients (35% vs 17%, P = .05). We conclude that MICA may represent novel a transplantation antigen recognized by human allogeneic T cells. This study was registered at ClinicalTrials.gov (Identifier NCT00506922).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:CanoPedroP,
pubmed-author:ChamplinRichard ERE,
pubmed-author:Del LimaMarcosM,
pubmed-author:Fernandez-VinaMarceloM,
pubmed-author:GiraltSergioS,
pubmed-author:HosingChitraC,
pubmed-author:KebriaeiPartowP,
pubmed-author:LiuPingP,
pubmed-author:ParmarSimritS,
pubmed-author:PatahPoliana APA,
pubmed-author:PesoaSusanaS,
pubmed-author:PopatUdayU,
pubmed-author:QazilbashMuzaffar HMH,
pubmed-author:RondonGabrielaG,
pubmed-author:ShpallElizabeth JEJ,
pubmed-author:StastnyPeterP,
pubmed-author:ZouYizhouY,
pubmed-author:de Padua SilvaLeandroL
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2884-7
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pubmed:meshHeading |
pubmed-meshheading:19654407-Adolescent,
pubmed-meshheading:19654407-Adult,
pubmed-meshheading:19654407-Aged,
pubmed-meshheading:19654407-Blood Donors,
pubmed-meshheading:19654407-Female,
pubmed-meshheading:19654407-Genes, MHC Class I,
pubmed-meshheading:19654407-Genotype,
pubmed-meshheading:19654407-Graft Rejection,
pubmed-meshheading:19654407-Graft vs Host Disease,
pubmed-meshheading:19654407-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19654407-Histocompatibility,
pubmed-meshheading:19654407-Histocompatibility Testing,
pubmed-meshheading:19654407-Humans,
pubmed-meshheading:19654407-Incidence,
pubmed-meshheading:19654407-Leukemia, Myeloid, Acute,
pubmed-meshheading:19654407-Male,
pubmed-meshheading:19654407-Middle Aged,
pubmed-meshheading:19654407-Prognosis,
pubmed-meshheading:19654407-Prospective Studies,
pubmed-meshheading:19654407-Risk Factors,
pubmed-meshheading:19654407-Survival Rate,
pubmed-meshheading:19654407-Treatment Outcome,
pubmed-meshheading:19654407-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease.
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pubmed:affiliation |
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article
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