Source:http://linkedlifedata.com/resource/pubmed/id/19654053
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-11-27
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| pubmed:abstractText |
The purpose of this study was to determine the effects of allopurinol (AL) on xanthine oxidoreductase (XOR) activity and uric acid (UA) levels in chickens. Thirty 5-week-old broilers were divided into three groups and fed 0 (control), 25 (AL25) or 50 (AL50) mg AL per kg of body mass for 5 weeks. Chicks were weighed twice weekly and leukocyte oxidative activity (LOA) and plasma purine levels were determined weekly in five birds per group. Chicks were sacrificed after 2 or 5 weeks, and samples from tissues were taken for analysis of XOR activity. Plasma UA concentrations were lower (P<0.001) and xanthine and hypoxanthine concentrations were greater (P<0.001) in AL25 and AL50 birds compared to controls, whereas no differences (P=0.904) were detected in allantoin concentrations. By week 5, body mass was reduced (P<0.001) to 84.0 and 65.1% of that in controls for AL25 and AL50 broilers, respectively, and LOA was 4.1 times greater (P<0.05) in AL25 compared to control birds. Liver XOR activity was increased by 1.1 and 1.2 times in AL25 and AL50 birds, but there was no change (P>0.05) in XOR activity in the pancreas and intestine. These results suggest that AL effect on XOR activity is tissue dependent.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allantoin,
http://linkedlifedata.com/resource/pubmed/chemical/Allopurinol,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/Uric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine Oxidase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1532-0456
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
151
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
12-7
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| pubmed:meshHeading |
pubmed-meshheading:19654053-Age Factors,
pubmed-meshheading:19654053-Allantoin,
pubmed-meshheading:19654053-Allopurinol,
pubmed-meshheading:19654053-Animals,
pubmed-meshheading:19654053-Blood Glucose,
pubmed-meshheading:19654053-Body Weight,
pubmed-meshheading:19654053-Chickens,
pubmed-meshheading:19654053-Dose-Response Relationship, Drug,
pubmed-meshheading:19654053-Enzyme Inhibitors,
pubmed-meshheading:19654053-Female,
pubmed-meshheading:19654053-Hypoxanthine,
pubmed-meshheading:19654053-Intestines,
pubmed-meshheading:19654053-Liver,
pubmed-meshheading:19654053-Male,
pubmed-meshheading:19654053-Oxidative Stress,
pubmed-meshheading:19654053-Pancreas,
pubmed-meshheading:19654053-Uric Acid,
pubmed-meshheading:19654053-Xanthine,
pubmed-meshheading:19654053-Xanthine Dehydrogenase,
pubmed-meshheading:19654053-Xanthine Oxidase
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| pubmed:year |
2010
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| pubmed:articleTitle |
Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens.
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| pubmed:affiliation |
Division of Animal & Nutritional Sciences, West Virginia University, Morgantown, WV 26506-6108, USA. mdcart@unileon.es
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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