Linked Life Data

19653667

Source:http://linkedlifedata.com/resource/pubmed/id/19653667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-8-28
pubmed:abstractText
The composition of a centrifuged product obtained from the fresh leaves and stems of Melissa officinalis and skin irritation in the reconstituted human epidermis (Episkin model) have been investigated in comparison to the EtOH-H(2)O (1:1) extract obtained by Soxhlet from the dried plant. Two new sulfated triterpenes (1 and 2) and two ionol derivatives have been isolated for the first time from Melissa officinalis together with caffeic and rosmarinic acids. The structures of compounds 1 and 2 were established by analysis of their spectroscopic data. Both the centrifuged material and its major constituents neither affected cell viability nor caused the release of pro-inflammatory mediators or the decrease of trans-epithelial electrical resistance (TEER) in the reconstituted human epidermis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1512-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Composition of the fresh leaves and stems of Melissa officinalis and evaluation of skin irritation in a reconstituted human epidermis model.
pubmed:affiliation
Dipartimento di Scienze Farmaceutiche, University of Salerno, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't