Linked Life Data

19653063

Source:http://linkedlifedata.com/resource/pubmed/id/19653063

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-8-26
pubmed:abstractText
Cerebrospinal fluid (CSF)-based neurochemical dementia diagnostics (NDD) is a well-established diagnostic tool for neurodegenerative disorders, including Alzheimer's disease (AD). However, the direct comparison of the concentrations of the biomarkers between laboratories is often very misleading, due to relatively high inter-laboratory discrepancies of normal/abnormal ranges (cutoff values). Therefore, an interpretation tool might be useful for centers performing NDD to facilitate a standardized, diagnostic-oriented reporting of the data on biomarkers. In this study, we present a simple, easy-to-implement algorithm allowing diagnostic-relevant categorization of patients according to the outcome of the CSF NDD results and, correspondingly, enabling reporting of the data to clinicians in a clear and easy-to-follow form. The algorithm is flexible and cutoff values independent, meaning each laboratory can easily supplement it with the cutoff values and normal/abnormal ranges according to the needs; the only prerequisite is to perform the standard CSF NDD assays (amyloid beta peptides and Tau/pTau).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1435-1463
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1163-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Neurochemical dementia diagnostics: a simple algorithm for interpretation of the CSF biomarkers.
pubmed:affiliation
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Germany. Piotr.Lewczuk@uk-erlangen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't