Linked Life Data

1965271

Source:http://linkedlifedata.com/resource/pubmed/id/1965271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-5-24
pubmed:abstractText
Intracellular pH changes in rat brain tissue were investigated during low or high extracellular pH induced by acetazolamide or sodium bicarbonate, respectively. Intracellular pH was measured by 31P-MRS in the brain of spontaneously breathing rats under intraperitoneal sodium pentobarbital anaesthesia. Extracellular pH was calculated from the results of blood gas analysis. After intravenous injection of sodium bicarbonate (280 mg/kg), the extracellular pH rose significantly (p less than 0.05) from 7.47 +/- 0.06 to 7.82 +/- 0.15 (mean +/- SE). After administration of acetazolamide (50 mg/kg), the extracellular pH dropped significantly (p less than 0.05) from 7.45 +/- 0.02 to 7.34 +/- 0.03. Despite the changes in extracellular pH, the intracellular pH of rat brain did not change significantly under either condition. The following four factors are thought to contribute to the maintenance of intracellular pH in the normal brain: 1) production and consumption of H+ by brain metabolism, 2) physicochemical buffering, 3) transmembrane transport of H+ and its equivalent, 4) compensatory adaptation of circulatory factors. These mechanisms are not disturbed in the brain of rats that are breathing spontaneously, because the cerebral circulation and energy metabolism are preserved in the normal range.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1419
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-7
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Intracellular pH regulation of normal rat brain: 31P-MRS study.
pubmed:affiliation
Department of Neurosurgery, Shimane Medical University, Izumo, Japan.
pubmed:publicationType
Journal Article