Linked Life Data

19652464

Source:http://linkedlifedata.com/resource/pubmed/id/19652464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-8-4
pubmed:abstractText
We searched a yeast genomic library for genes that conferred methylmercury resistance to yeast. Ymr258c was identified as a factor that conferred strong methylmercury resistance when overexpressed in budding yeast. Ymr258c is regarded as one of the F-box proteins, i.e., component factors of the Skp1/Cullin/F-box protein (SCF) complex that functions as a ubiquitin ligase in the ubiquitin-proteasome system. In this study, Ymr258c was demonstrated to function as an F-box protein to reduce methylmercury toxicity. The overexpression of Ymr258c might promote the ubiquitination of proteins that are involved in the enhancement of methylmercury toxicity, and thereby promote their degradation by proteasomes to reduce methylmercury toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1880-3989
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
413-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae.
pubmed:publicationType
Letter, Research Support, Non-U.S. Gov't