|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003232,
umls-concept:C0010423,
umls-concept:C0012854,
umls-concept:C0014834,
umls-concept:C0043309,
umls-concept:C0205431,
umls-concept:C0439611,
umls-concept:C0439855,
umls-concept:C0936012,
umls-concept:C0949782,
umls-concept:C0962460,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
|
pubmed:issue |
Pt 8
|
|
pubmed:dateCreated |
2009-8-4
|
|
pubmed:abstractText |
Crystals of a complex formed between the 59 kDa N-terminal fragment of the Escherichia coli DNA gyrase A subunit (also known as the breakage-reunion domain) and the antibiotic simocyclinone D8 were grown by vapour diffusion. The complex crystallized with I-centred orthorhombic symmetry and X-ray data were recorded to a resolution of 2.75 A from a single crystal at the synchrotron. DNA gyrase is an essential bacterial enzyme and thus represents an attractive target for drug development.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-11079799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-12570764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-15728908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-16369093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-16369096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-17397985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-1847377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-18755053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-5700707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-9080608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19652356-9278055
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1744-3091
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
846-8
|
|
pubmed:dateRevised |
2011-8-3
|
|
pubmed:meshHeading |
pubmed-meshheading:19652356-Coumarins,
pubmed-meshheading:19652356-Crystallization,
pubmed-meshheading:19652356-Crystallography, X-Ray,
pubmed-meshheading:19652356-DNA Damage,
pubmed-meshheading:19652356-DNA Gyrase,
pubmed-meshheading:19652356-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:19652356-Escherichia coli,
pubmed-meshheading:19652356-Glycosides,
pubmed-meshheading:19652356-Molecular Conformation
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase.
|
|
pubmed:affiliation |
Department of Biological Chemistry, John Innes Centre, Norwich NR4 7UH, England.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
