rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
26
|
pubmed:dateCreated |
2009-9-9
|
pubmed:databankReference |
|
pubmed:abstractText |
Sorafenib is an oral multikinase inhibitor that targets the Ras/Raf/MEK/ERK mitogenic signaling pathway and the angiogenic receptor tyrosine kinases, vascular endothelial growth factor receptor 2 and platelet-derived growth factor receptor beta. We evaluated the antitumor response and tolerability of sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer (NSCLC), most of whom had received prior platinum-based chemotherapy.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
1527-7755
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
10
|
pubmed:volume |
27
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4274-80
|
pubmed:meshHeading |
pubmed-meshheading:19652055-Aged,
pubmed-meshheading:19652055-Antineoplastic Agents,
pubmed-meshheading:19652055-Benzenesulfonates,
pubmed-meshheading:19652055-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19652055-Diarrhea,
pubmed-meshheading:19652055-Drug Resistance, Neoplasm,
pubmed-meshheading:19652055-Fatigue,
pubmed-meshheading:19652055-Female,
pubmed-meshheading:19652055-Humans,
pubmed-meshheading:19652055-Lung Neoplasms,
pubmed-meshheading:19652055-Male,
pubmed-meshheading:19652055-Middle Aged,
pubmed-meshheading:19652055-Nausea,
pubmed-meshheading:19652055-Neoplasm Recurrence, Local,
pubmed-meshheading:19652055-Pyridines,
pubmed-meshheading:19652055-Survival Analysis,
pubmed-meshheading:19652055-Treatment Outcome
|
pubmed:year |
2009
|
pubmed:articleTitle |
Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer.
|
pubmed:affiliation |
The M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 432, Houston, TX 77030-4009, USA. gblumens@mdanderson.org
|
pubmed:publicationType |
Journal Article,
Multicenter Study,
Clinical Trial, Phase II
|