rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-9-18
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pubmed:abstractText |
Neurotensin (NT) is a neuropeptide with antinociceptive effects that are mediated through NT receptors, of which there are three known subtypes (NTS1, NTS2, and NTS3). Morphine is a mu-opioid receptor agonist commonly used for pain treatment but is associated with side effects that can be serious. We hypothesize that selective NT receptor agonists may represent a novel class of analgesics and their use in conjunction with morphine will have synergistic properties which may reduce the dose of morphine administered and its side effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotensin,
http://linkedlifedata.com/resource/pubmed/chemical/Ntsr2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotensin,
http://linkedlifedata.com/resource/pubmed/chemical/levocabastine,
http://linkedlifedata.com/resource/pubmed/chemical/neurotensin 69L
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1872-6240
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
1294
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-8
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pubmed:meshHeading |
pubmed-meshheading:19651107-Analgesics,
pubmed-meshheading:19651107-Analgesics, Opioid,
pubmed-meshheading:19651107-Animals,
pubmed-meshheading:19651107-Dose-Response Relationship, Drug,
pubmed-meshheading:19651107-Drug Synergism,
pubmed-meshheading:19651107-Hot Temperature,
pubmed-meshheading:19651107-Male,
pubmed-meshheading:19651107-Morphine,
pubmed-meshheading:19651107-Neurotensin,
pubmed-meshheading:19651107-Pain,
pubmed-meshheading:19651107-Pain Measurement,
pubmed-meshheading:19651107-Peptide Fragments,
pubmed-meshheading:19651107-Piperidines,
pubmed-meshheading:19651107-Rats,
pubmed-meshheading:19651107-Rats, Sprague-Dawley,
pubmed-meshheading:19651107-Receptors, Neurotensin,
pubmed-meshheading:19651107-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
NT69L, a novel analgesic, shows synergy with morphine.
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pubmed:affiliation |
Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Jacksonville, Florida, USA. boules.mona@mayo.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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