Linked Life Data

1965090

Source:http://linkedlifedata.com/resource/pubmed/id/1965090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-5-23
pubmed:abstractText
Pretreatment to guinea pigs with sc isoprenaline (Iso) 10 micrograms/kg tid x 7 d reduced the effect of Iso on protecting histamine-induced asthma and decreased its pD2 values in relaxing isolated tracheal strip. This treatment did not change the asthmatic effect induced by histamine and the effect of Iso on positive chronotropic action, but elevated the blood pressure. These results suggest that it is easier to develop the tolerance of beta 2-adrenoceptors of respiratory smooth muscles than that of beta 1-adrenoceptors of heart. Radioligand binding assay showed that the treatment decreased the number of binding sites of beta-adrenoceptors on lungs of guinea pigs but did not change the binding affinity.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Difference of tolerances to isoprenaline between tracheal and vascular smooth muscles and cardiac conduction system in guinea pigs].
pubmed:affiliation
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
pubmed:publicationType
Journal Article, English Abstract