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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2009-12-3
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pubmed:abstractText |
New linear and cyclic guanidines were synthesized and tested in vitro for their antifungal activity toward clinically relevant strains of Candida species, in comparison to fluconazole. Macrocyclic compounds showed a minimum inhibitory concentration in the micromolar range and a biological activity profile in some cases better than that of fluconazole. One macrocyclic derivative was also tested against Aspergillus species and showed high antifungal activity comparable to that of amphotericin B and itraconazole.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:BottaMaurizioM,
pubmed-author:CastagnoloDanieleD,
pubmed-author:ConaAlessandraA,
pubmed-author:D'ArezzoSilviaS,
pubmed-author:DoriaDeniseD,
pubmed-author:FaddaGiovanniG,
pubmed-author:FracassoMaria EnricaME,
pubmed-author:ManettiFabrizioF,
pubmed-author:PosteraroBrunellaB,
pubmed-author:RaffiFrancescoF,
pubmed-author:RajamäkiSuviS,
pubmed-author:SanguinettiMaurizioM,
pubmed-author:ViscaPaoloP,
pubmed-author:ZizzariAlessandra TAT
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7376-9
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp.
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pubmed:affiliation |
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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