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rdf:type |
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lifeskim:mentions |
umls-concept:C0015730,
umls-concept:C0032105,
umls-concept:C0035696,
umls-concept:C0152096,
umls-concept:C0456603,
umls-concept:C0521457,
umls-concept:C0678804,
umls-concept:C0936012,
umls-concept:C1418253,
umls-concept:C1511790,
umls-concept:C1858460
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-2
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|
pubmed:abstractText |
Non-invasive prenatal diagnosis of chromosome aneuploidies has been achieved by measuring the ratio of two alleles of a single nucleotide polymorphism (SNP) in circulating placental mRNA (the RNA-SNP allelic ratio approach) in maternal plasma. We investigated the feasibility of applying this approach for the non-invasive prenatal detection of fetal trisomy 18.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-0223
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1031-7
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pubmed:meshHeading |
pubmed-meshheading:19650060-Alleles,
pubmed-meshheading:19650060-Blood Chemical Analysis,
pubmed-meshheading:19650060-Chromosomes, Human, Pair 18,
pubmed-meshheading:19650060-Feasibility Studies,
pubmed-meshheading:19650060-Female,
pubmed-meshheading:19650060-Humans,
pubmed-meshheading:19650060-Mothers,
pubmed-meshheading:19650060-Plasminogen Activator Inhibitor 2,
pubmed-meshheading:19650060-Polymorphism, Single Nucleotide,
pubmed-meshheading:19650060-Pregnancy,
pubmed-meshheading:19650060-Pregnancy Trimester, First,
pubmed-meshheading:19650060-Prenatal Diagnosis,
pubmed-meshheading:19650060-RNA, Messenger,
pubmed-meshheading:19650060-Sensitivity and Specificity,
pubmed-meshheading:19650060-Trisomy
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pubmed:year |
2009
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pubmed:articleTitle |
Non-invasive prenatal detection of fetal trisomy 18 by RNA-SNP allelic ratio analysis using maternal plasma SERPINB2 mRNA: a feasibility study.
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pubmed:affiliation |
Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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