Linked Life Data

19649697

Source:http://linkedlifedata.com/resource/pubmed/id/19649697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-10-2
pubmed:abstractText
Forkhead box protein A1 (FoxA1) is an evolutionarily conserved winged helix transcription factor with diverse regulatory functions. However, little is known about the role of FoxA1 in acute lung injury (ALI) and pulmonary cell injury. In this study, an in vivo model was employed whereby rats were administered an intravenous injection of oleic acid (OA, 0.1 ml/kg), and alveolar type II epithelial cells (AT-2 cells) injury was induced by hydrogen peroxide (H(2)O(2)) in vitro. OA injection resulted in lung injury and AT-2 cells apoptosis in vivo. OA injection and H(2)O(2) upregulated FoxA1 mRNA and protein in lung tissue of the in vivo ALI model and in H(2)O(2) challenged AT-2 cells. Overexpression of FoxA1 promoted apoptosis, whereas FoxA1 deficiency, induced by antisense oligonucleotides, decreased AT-2 cells apoptosis induced by H(2)O(2), as shown by flow cytometry. These results suggest that FoxA1 may play an important role in ALI by promoting apoptosis of pulmonary epithelial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1573-2576
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
322-32
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A role for forkhead box A1 in acute lung injury.
pubmed:affiliation
Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Hunan, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't