19649631

Source:http://linkedlifedata.com/resource/pubmed/id/19649631

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003250, umls-concept:C0030705, umls-concept:C0031327, umls-concept:C0036043, umls-concept:C0205269, umls-concept:C0206686, umls-concept:C2713009
pubmed:issue	4
pubmed:dateCreated	2010-1-20
pubmed:abstractText	Insulin-like growth factor 1 receptor signaling through upregulation of the stimulatory ligand IGF-II has been implicated in the pathogenesis of adrenocortical carcinoma. As there is a paucity of effective therapies, this dose expansion cohort of a phase 1 study was undertaken to determine the safety, tolerability, pharmacokinetics, and effects on endocrine markers of figitumumab in patients with adrenocortical carcinoma.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/K12 CA090628-05
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7806519
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1432-0843
pubmed:author	pubmed-author:BatzelGretchen NGN, pubmed-author:GualbertoAntonioA, pubmed-author:HaluskaPaulP, pubmed-author:HammerGary DGD, pubmed-author:OlmosDavidD, pubmed-author:PaccagnellaM LuisaML, pubmed-author:SchteingartDavidD, pubmed-author:WordenFrankF, pubmed-author:YinDonghuaD, pubmed-author:de BonoJohann SJS
pubmed:issnType	Electronic
pubmed:volume	65
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	765-73
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:19649631-Adrenal Cortex Neoplasms, pubmed-meshheading:19649631-Adrenocortical Carcinoma, pubmed-meshheading:19649631-Adult, pubmed-meshheading:19649631-Aged, pubmed-meshheading:19649631-Anorexia, pubmed-meshheading:19649631-Antibodies, Monoclonal, pubmed-meshheading:19649631-Area Under Curve, pubmed-meshheading:19649631-Cohort Studies, pubmed-meshheading:19649631-Drug Administration Schedule, pubmed-meshheading:19649631-Fatigue, pubmed-meshheading:19649631-Female, pubmed-meshheading:19649631-Growth Hormone, pubmed-meshheading:19649631-Humans, pubmed-meshheading:19649631-Hyperglycemia, pubmed-meshheading:19649631-Infusions, Intravenous, pubmed-meshheading:19649631-Insulin, pubmed-meshheading:19649631-Male, pubmed-meshheading:19649631-Metabolic Clearance Rate, pubmed-meshheading:19649631-Middle Aged, pubmed-meshheading:19649631-Nausea, pubmed-meshheading:19649631-Receptor, IGF Type 1, pubmed-meshheading:19649631-Treatment Outcome, pubmed-meshheading:19649631-Young Adult
pubmed:year	2010
pubmed:articleTitle	Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma.

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