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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1991-5-23
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pubmed:abstractText |
The nitric oxide (NO) synthesis inhibitor NG-monomethyl L-arginine (L-NMMA) reduced NANC-mediated relaxations of isolated strips of the rat gastric fundus elicited by low frequencies or short periods of field stimulation, but D-NMMA had no effect. The inhibitory effect of L-NMMA on NANC-mediated relaxations was partially reversed by L-arginine but was not affected by D-arginine. A VIP antibody abolished the relaxant response to VIP and reduced the responses to stimulation. Residual responses to stimulation in the presence of VIP antibody were further reduced by L-NMMA. The tone of the fundus strip was slightly increased by L-NMMA and slightly reduced by L-arginine. The relaxation produced by VIP was slightly reduced by L-NMMA and enhanced by L-arginine. Relaxations produced by peptide histidine isoleucine, sodium nitroprusside or isoprenaline were not affected by L-NMMA or L-arginine. The results suggest that NO as well as VIP is involved in NANC-mediated relaxations of the rat gastric fundus.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
4
|
pubmed:volume |
191
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
303-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1964906-Animals,
pubmed-meshheading:1964906-Arginine,
pubmed-meshheading:1964906-Autonomic Nervous System,
pubmed-meshheading:1964906-Electric Stimulation,
pubmed-meshheading:1964906-Gastric Fundus,
pubmed-meshheading:1964906-Male,
pubmed-meshheading:1964906-Muscle, Smooth,
pubmed-meshheading:1964906-Muscle Relaxation,
pubmed-meshheading:1964906-Nitric Oxide,
pubmed-meshheading:1964906-Rats,
pubmed-meshheading:1964906-Rats, Inbred Strains,
pubmed-meshheading:1964906-Synaptic Transmission,
pubmed-meshheading:1964906-Vasoactive Intestinal Peptide,
pubmed-meshheading:1964906-omega-N-Methylarginine
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pubmed:year |
1990
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pubmed:articleTitle |
Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus.
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pubmed:affiliation |
Department of Pharmacology, University of Melbourne, Victoria, Australia.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|