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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-19
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/PDB/3HA6,
http://linkedlifedata.com/resource/pubmed/xref/PDB/3HA8,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080197,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080198,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080199,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080200,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080201,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080202,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080203,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080204,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080205,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080206,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080207,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080208,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080209,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080210,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080211,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080212,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080213,
http://linkedlifedata.com/resource/pubmed/xref/PubChem-Substance/81080214
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pubmed:abstractText |
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal. We report the synthesis and interrogation of an 800-million-member DNA-encoded library in which small molecules are covalently attached to an encoding oligonucleotide. The library was assembled by a combination of chemical and enzymatic synthesis, and interrogated by affinity selection. We describe methods for the selection and deconvolution of the chemical display library, and the discovery of inhibitors for two enzymes: Aurora A kinase and p38 MAP kinase.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1552-4469
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pubmed:author |
pubmed-author:AcharyaRaksha ARA,
pubmed-author:Arico-MuendelChristopher CCC,
pubmed-author:BelyanskayaSvetlana LSL,
pubmed-author:BenjaminDennis RDR,
pubmed-author:CarlsonNeil RNR,
pubmed-author:CentrellaPaolo APA,
pubmed-author:ChinCynthia SCS,
pubmed-author:ClarkMatthew AMA,
pubmed-author:CreaserSteffen PSP,
pubmed-author:CuozzoJohn WJW,
pubmed-author:DavieChristopher PCP,
pubmed-author:DingYunY,
pubmed-author:FanLiL,
pubmed-author:FranklinG JosephGJ,
pubmed-author:FranzenKurt DKD,
pubmed-author:GefterMalcolm LML,
pubmed-author:HallSteven ESE,
pubmed-author:HansenNils J VNJ,
pubmed-author:IsraelDavid IDI,
pubmed-author:JiangJinweiJ,
pubmed-author:KavaranaMalcolm JMJ,
pubmed-author:KelleyMichael SMS,
pubmed-author:KollmannChristopher SCS,
pubmed-author:LindKennethK,
pubmed-author:LujiaTangT,
pubmed-author:MataruseSibongileS,
pubmed-author:MedeirosPatricia FPF,
pubmed-author:MesserJeffrey AJA,
pubmed-author:MorganBarry ABA,
pubmed-author:MyersPaulP,
pubmed-author:O'KeefeHeatherH,
pubmed-author:OliffMatthew CMC,
pubmed-author:RiseCecil ECE,
pubmed-author:SatzAlexander LAL,
pubmed-author:SkinnerSteven RSR,
pubmed-author:SvendsenJennifer LJL,
pubmed-author:WagnerRichard WRW,
pubmed-author:YaoGangG,
pubmed-author:ZhaoBaoguangB,
pubmed-author:van VlotenKurtK
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
647-54
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pubmed:dateRevised |
2011-7-11
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Design, synthesis and selection of DNA-encoded small-molecule libraries.
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pubmed:affiliation |
Praecis Pharmaceuticals, Waltham, Massachusetts, USA
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