Linked Life Data

19648499

Source:http://linkedlifedata.com/resource/pubmed/id/19648499

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-20
pubmed:abstractText
We performed a whole genome QTL analysis to confirm the existence of QTL affecting fatty acid composition and to investigate the effects of additive, dominance, imprinting, and epistatic interactions between QTL in an F(2) resource population. The F(2) population, comprising 166 pigs, was obtained by crossing a Duroc boar and a Meishan sow. The F(2) population was measured for fatty acid composition and was used for whole genome QTL analysis, using a total of 180 microsatellite markers. The suggestive and significant thresholds were equivalent to likelihood ratio test statistics (LRT) of 13.7 and 20.5, respectively. For single QTL analysis, 2 suggestive QTL and 1 significant QTL were detected. Suggestive QTL for C14:0 and C16:1 were identified on chromosomes 12 and 7, respectively, and a significant QTL for C18:2 was detected on chromosome 5 with the greatest LRT of 22.9. For C14:0, a significant QTL with paternal imprinting effect was also detected on chromosome 12, where the locus was in the same region as an additive QTL effect, with a large LRT of 24.2. The suggestive QTL on chromosome 7 was not significant when correction for backfat thickness was included. For epistatic QTL analysis, a total of 5 epistatic pairs were located on chromosomes 4, 5, 9, and 16. The same epistatic pairs were significant when correction for backfat thickness was included. The individual QTL identified in the single QTL analysis and in the epistatic QTL analysis were not the same loci, except for C18:2. For C14:0, an epistatic QTL pair was detected on chromosome 16, with the least P-value of 4.9 x 10(-12). The present study constitutes one of the first reports on the mapping of imprinted QTL and epistatic pairs of QTL affecting fatty acid composition in a swine population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1525-3163
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3470-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The effects of single and epistatic quantitative trait loci for fatty acid composition in a Meishan x Duroc crossbred population.
pubmed:affiliation
National Livestock Breeding Center, Odakura, Nishigo, Fukushima 961-8511, Japan. y0uemoto@nlbc.go.jp
pubmed:publicationType
Journal Article