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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-11-25
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pubmed:abstractText |
The synthesis of (2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and its enantiomers, analogs of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol ((RS)-9) is described. Compounds were tested for electrographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for alpha(1)-, alpha(2)- and beta(1)-adrenoceptors binding affinities. The antagonist potency of the new compounds was compared with carvedilol and (RS)-9.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1768-3254
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5103-11
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pubmed:meshHeading |
pubmed-meshheading:19647907-2-Propanol,
pubmed-meshheading:19647907-Adrenergic Antagonists,
pubmed-meshheading:19647907-Animals,
pubmed-meshheading:19647907-Antihypertensive Agents,
pubmed-meshheading:19647907-Carbazoles,
pubmed-meshheading:19647907-Ileum,
pubmed-meshheading:19647907-Male,
pubmed-meshheading:19647907-Molecular Structure,
pubmed-meshheading:19647907-Propanolamines,
pubmed-meshheading:19647907-Rabbits,
pubmed-meshheading:19647907-Rats,
pubmed-meshheading:19647907-Rats, Wistar,
pubmed-meshheading:19647907-Stereoisomerism
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2.
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pubmed:affiliation |
Faculty of Chemistry, Rzeszów University of Technology, 6 Powsta?ców Warszawy Avenue, 35-959 Rzeszów, Poland. ggroszek@prz.edu.pl
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pubmed:publicationType |
Journal Article
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