Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
42
pubmed:dateCreated
2009-9-14
pubmed:abstractText
Adding poly(gamma-glutamic acid) nano-particles (gamma-PGA-NPs), a safe, natural material, to subcutaneous immunization with influenza virus hemagglutinin (HA) vaccine increases the protective immune responses against influenza virus in mice. Here, we examined whether intranasal administration of the HA vaccine with gamma-PGA-NPs would induce protection from influenza virus challenge in mice. Intranasal immunization with the mixture of gamma-PGA-NPs and HA vaccine from an influenza virus strain A/PR/8/34 (H1N1) or A/New Caledonia/20/99 (H1N1) enhanced protection of mice from A/PR/8/34 infection. Intranasal immunization with A/New Caledonia/20/99 HA vaccine and gamma-PGA-NPs induced cell-mediated immune responses and neutralizing antibody production for both A/New Caledonia/20/99 and A/PR/8/34. These data suggest that gamma-PGA-NPs may have potential for clinical applications as a mucosal adjuvant.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1873-2518
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5896-905
pubmed:meshHeading
pubmed-meshheading:19647814-Adjuvants, Immunologic, pubmed-meshheading:19647814-Administration, Intranasal, pubmed-meshheading:19647814-Animals, pubmed-meshheading:19647814-Antibodies, Viral, pubmed-meshheading:19647814-Cell Proliferation, pubmed-meshheading:19647814-Cytokines, pubmed-meshheading:19647814-Female, pubmed-meshheading:19647814-Hemagglutinin Glycoproteins, Influenza Virus, pubmed-meshheading:19647814-Immunity, Cellular, pubmed-meshheading:19647814-Influenza A Virus, H1N1 Subtype, pubmed-meshheading:19647814-Influenza Vaccines, pubmed-meshheading:19647814-Mice, pubmed-meshheading:19647814-Mice, Inbred BALB C, pubmed-meshheading:19647814-Nanoparticles, pubmed-meshheading:19647814-Neutralization Tests, pubmed-meshheading:19647814-Orthomyxoviridae Infections, pubmed-meshheading:19647814-Polyglutamic Acid, pubmed-meshheading:19647814-Spleen
pubmed:year
2009
pubmed:articleTitle
Poly(gamma-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice.
pubmed:affiliation
Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't