| pubmed-article:19647225 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19647225 | lifeskim:mentions | umls-concept:C0085281 | lld:lifeskim |
| pubmed-article:19647225 | lifeskim:mentions | umls-concept:C1706586 | lld:lifeskim |
| pubmed-article:19647225 | lifeskim:mentions | umls-concept:C1519346 | lld:lifeskim |
| pubmed-article:19647225 | lifeskim:mentions | umls-concept:C0812215 | lld:lifeskim |
| pubmed-article:19647225 | lifeskim:mentions | umls-concept:C2746015 | lld:lifeskim |
| pubmed-article:19647225 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19647225 | pubmed:dateCreated | 2009-8-3 | lld:pubmed |
| pubmed-article:19647225 | pubmed:abstractText | Ras activation is common to many human cancers and promotes cell proliferation and survival by initiating multiple signaling cascades. Accordingly, Ras-transformed cells are generally considered too resourceful to become addicted to a single effector. In contrast to this tenet, we now demonstrate an absolute, cell autonomous requirement for Raf-1 in the development and maintenance of Ras-induced skin epidermis tumors. Mechanistically, Raf-1 functions as an endogenous inhibitor dimming the activity of the Rho-dependent kinase Rok-alpha in the context of a Ras-induced Raf-1:Rok-alpha complex. Raf-1-induced Rok-alpha inhibition allows the phosphorylation of STAT3 and Myc expression and promotes dedifferentiation in Ras-induced tumors. These data link the Raf-1:Rok-alpha complex to STAT3/Myc activation and delineate a pathway crucial for cell fate decision in Ras-induced tumorigenesis. | lld:pubmed |
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| pubmed-article:19647225 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19647225 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19647225 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19647225 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19647225 | pubmed:issn | 1878-3686 | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:BaccariniManu... | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:SibiliaMariaM | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:KernFlorianF | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:Galabova-Kova... | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:EhrenreiterKa... | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:VelamoorVanis... | lld:pubmed |
| pubmed-article:19647225 | pubmed:author | pubmed-author:MeisslKatrinK | lld:pubmed |
| pubmed-article:19647225 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19647225 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:19647225 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:19647225 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19647225 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19647225 | pubmed:pagination | 149-60 | lld:pubmed |
| pubmed-article:19647225 | pubmed:dateRevised | 2011-4-6 | lld:pubmed |
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| pubmed-article:19647225 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19647225 | pubmed:articleTitle | Raf-1 addiction in Ras-induced skin carcinogenesis. | lld:pubmed |
| pubmed-article:19647225 | pubmed:affiliation | Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria. | lld:pubmed |
| pubmed-article:19647225 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19647225 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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