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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-11-17
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pubmed:abstractText |
Naturally occurring regulatory T-cells (Treg) exhibit impaired function in patients with relapsing-remitting multiple sclerosis (RRMS) resulting from an age-inappropriate disproportion between prevalences of newly generated CD31-coexpressing naive Treg and long-lived memory Treg in the periphery. Recent evidence suggests that the immunomodulatory action of glatiramer acetate (GA) includes effects on Treg function and frequencies. We prospectively assessed suppressive activities and frequencies of Treg and Treg subsets in 15 patients with RRMS undergoing long-term therapy with GA. Treatment for up to six months reconstituted naive Treg and increased total Treg numbers with concomitant reversion of the Treg defect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/IL2RA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/copolymer 1
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1872-8421
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
216
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-7
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pubmed:meshHeading |
pubmed-meshheading:19646767-Adult,
pubmed-meshheading:19646767-Antigens, CD31,
pubmed-meshheading:19646767-Antigens, CD4,
pubmed-meshheading:19646767-Antigens, Surface,
pubmed-meshheading:19646767-Biological Markers,
pubmed-meshheading:19646767-Cell Count,
pubmed-meshheading:19646767-Cell Proliferation,
pubmed-meshheading:19646767-Cells, Cultured,
pubmed-meshheading:19646767-Coculture Techniques,
pubmed-meshheading:19646767-Forkhead Transcription Factors,
pubmed-meshheading:19646767-Humans,
pubmed-meshheading:19646767-Immunologic Memory,
pubmed-meshheading:19646767-Immunomodulation,
pubmed-meshheading:19646767-Immunosuppressive Agents,
pubmed-meshheading:19646767-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:19646767-Multiple Sclerosis,
pubmed-meshheading:19646767-Peptides,
pubmed-meshheading:19646767-Prospective Studies,
pubmed-meshheading:19646767-T-Lymphocytes, Regulatory,
pubmed-meshheading:19646767-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4(+)CD25(+)FOXP3(+)CD31(+) T-cells in patients with multiple sclerosis.
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pubmed:affiliation |
Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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