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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Suppl 52
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pubmed:dateCreated |
2009-8-3
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pubmed:abstractText |
The cytokine profile suggests that giant cell arteritis (GCA) is a Th1-driven disease, in which local IFN-gamma plays a critical role in the development of a systemic arteritis. IL-12 is a potent inducer of IFN-gamma and is critically involved in biasing an immune response towards a Th1 pathway. The purpose of this study was to investigate whether there was an association between an IL-12 gene polymorphism (-1188 A/C 3UTR) and disease susceptibility for GCA and two other age-related inflammatory conditions, such as polymyalgia rheumatica (PMR) and elderly-onset rheumatoid arthritis (EORA). Furthermore, we attempted to correlate such polymorphism with in vitro IL-12 production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0392-856X
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pubmed:author |
pubmed-author:Agudo-BilbaoMM,
pubmed-author:Alvarez-RodriguezLL,
pubmed-author:BlancoRR,
pubmed-author:CalvoJJ,
pubmed-author:Carrasco-MarínEE,
pubmed-author:CorralesAA,
pubmed-author:Fernandez PrietoLL,
pubmed-author:López-HoyosMM,
pubmed-author:Martínez-TaboadaV MVM,
pubmed-author:MatoMM,
pubmed-author:Rodriguez-ValverdeVV,
pubmed-author:Ruiz SotoMM,
pubmed-author:RuizTT
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S14-8
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pubmed:meshHeading |
pubmed-meshheading:19646340-3' Untranslated Regions,
pubmed-meshheading:19646340-Aged,
pubmed-meshheading:19646340-Aging,
pubmed-meshheading:19646340-Arthritis, Rheumatoid,
pubmed-meshheading:19646340-Female,
pubmed-meshheading:19646340-Genetic Predisposition to Disease,
pubmed-meshheading:19646340-Genotype,
pubmed-meshheading:19646340-Giant Cell Arteritis,
pubmed-meshheading:19646340-Humans,
pubmed-meshheading:19646340-Interleukin-12,
pubmed-meshheading:19646340-Male,
pubmed-meshheading:19646340-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19646340-Polymyalgia Rheumatica
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pubmed:articleTitle |
Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis.
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pubmed:affiliation |
Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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