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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-8-11
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pubmed:abstractText |
The hypothesis of this study was that synovial factors playing a pivotal role in the pathogenesis of osteoarthritis (OA) and thus gene expression in the synovium would be altered at the initial stage of OA. The aims of this study were to identify the candidate genes in synovium related to OA initiation, to evaluate cartilage degeneration after knockdown of the gene using small interfering RNA (siRNA) gene silencing in the knee joints at the initial stage of OA, and to determine the potential role of the knocked-down gene in OA initiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2372-80
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19644873-Animals,
pubmed-meshheading:19644873-Anterior Cruciate Ligament,
pubmed-meshheading:19644873-Arthritis, Experimental,
pubmed-meshheading:19644873-Cartilage, Articular,
pubmed-meshheading:19644873-Cathepsin K,
pubmed-meshheading:19644873-Cathepsins,
pubmed-meshheading:19644873-Cysteine Endopeptidases,
pubmed-meshheading:19644873-Disease Progression,
pubmed-meshheading:19644873-Down-Regulation,
pubmed-meshheading:19644873-Female,
pubmed-meshheading:19644873-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:19644873-Gene Silencing,
pubmed-meshheading:19644873-Osteoarthritis,
pubmed-meshheading:19644873-RNA, Messenger,
pubmed-meshheading:19644873-RNA, Small Interfering,
pubmed-meshheading:19644873-Rabbits,
pubmed-meshheading:19644873-Synovial Membrane,
pubmed-meshheading:19644873-Transduction, Genetic
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pubmed:year |
2009
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pubmed:articleTitle |
Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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