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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-9-17
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pubmed:abstractText |
According to previous observations, the gene encoding the phosphatidylinositol-4-phosphate 5-kinase II alpha (PIP5K2A) is associated with schizophrenia. Specifically, the mutation (N251S)PIP5K2A has been discovered in schizophrenic patients but not in healthy individuals. A defect of the excitatory amino acid transporter EAAT3 has similarly been implicated in the development of schizophrenia. The present study thus explored whether PIP5K2A is involved in the regulation of EAAT3 activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1432-2072
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pubmed:author |
pubmed-author:FöllerMichaelM,
pubmed-author:FedorenkoOlgaO,
pubmed-author:GehringEva-MariaEM,
pubmed-author:IvanovaSvetlanaS,
pubmed-author:LangFlorianF,
pubmed-author:LangUndine EUE,
pubmed-author:SeebohmGuiscardG,
pubmed-author:SemkeArkadijA,
pubmed-author:SopjaniMentorM,
pubmed-author:Strutz-SeebohmNathalieN,
pubmed-author:TangCaiC,
pubmed-author:UrecheOana NON
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pubmed:issnType |
Electronic
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pubmed:volume |
206
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-35
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pubmed:meshHeading |
pubmed-meshheading:19644675-Animals,
pubmed-meshheading:19644675-Blotting, Western,
pubmed-meshheading:19644675-Cell Line,
pubmed-meshheading:19644675-Cell Membrane,
pubmed-meshheading:19644675-Excitatory Amino Acid Transporter 3,
pubmed-meshheading:19644675-Female,
pubmed-meshheading:19644675-Glutamic Acid,
pubmed-meshheading:19644675-Humans,
pubmed-meshheading:19644675-Kidney,
pubmed-meshheading:19644675-Microscopy, Confocal,
pubmed-meshheading:19644675-Mutation,
pubmed-meshheading:19644675-Oocytes,
pubmed-meshheading:19644675-Patch-Clamp Techniques,
pubmed-meshheading:19644675-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:19644675-Schizophrenia,
pubmed-meshheading:19644675-Xenopus
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pubmed:year |
2009
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pubmed:articleTitle |
PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3.
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pubmed:affiliation |
Department of Physiology, University of Tuebingen, Gmelinstr. 5, 72076 Tuebingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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