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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-12
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pubmed:abstractText |
To understand sensory representation in cortex, it is crucial to identify its constituent cellular components based on cell-type-specific criteria. With the identification of cell types, an important question can be addressed: to what degree does the cellular properties of neurons depend on cortical location? We tested this question using pyramidal neurons in layer 5 (L5) because of their role in providing major cortical output to subcortical targets. Recently developed transgenic mice with cell-type-specific enhanced green fluorescent protein labeling of neuronal subtypes allow reliable identification of 2 cortical cell types in L5 throughout the entire neocortex. A comprehensive investigation of anatomical and functional properties of these 2 cell types in visual and somatosensory cortex demonstrates that, with important exceptions, most properties appear to be cell-type-specific rather than dependent on cortical area. This result suggests that although cortical output neurons share a basic layout throughout the sensory cortex, fine differences in properties are tuned to the cortical area in which neurons reside.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1460-2199
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
826-36
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pubmed:meshHeading |
pubmed-meshheading:19643810-Analysis of Variance,
pubmed-meshheading:19643810-Animals,
pubmed-meshheading:19643810-Biophysical Processes,
pubmed-meshheading:19643810-Cell Count,
pubmed-meshheading:19643810-Cholera Toxin,
pubmed-meshheading:19643810-Dendrites,
pubmed-meshheading:19643810-Electric Stimulation,
pubmed-meshheading:19643810-Excitatory Postsynaptic Potentials,
pubmed-meshheading:19643810-Galactosyltransferases,
pubmed-meshheading:19643810-Glutamate Decarboxylase,
pubmed-meshheading:19643810-Green Fluorescent Proteins,
pubmed-meshheading:19643810-Membrane Potentials,
pubmed-meshheading:19643810-Mice,
pubmed-meshheading:19643810-Mice, Inbred C57BL,
pubmed-meshheading:19643810-Mice, Transgenic,
pubmed-meshheading:19643810-Neocortex,
pubmed-meshheading:19643810-Neural Pathways,
pubmed-meshheading:19643810-Patch-Clamp Techniques,
pubmed-meshheading:19643810-Phosphopyruvate Hydratase,
pubmed-meshheading:19643810-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:19643810-Pyramidal Cells,
pubmed-meshheading:19643810-Somatosensory Cortex,
pubmed-meshheading:19643810-Thalamus
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pubmed:year |
2010
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pubmed:articleTitle |
Cell-type specific properties of pyramidal neurons in neocortex underlying a layout that is modifiable depending on the cortical area.
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pubmed:affiliation |
Institute for Neuroscience of Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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