Linked Life Data

1964212

Source:http://linkedlifedata.com/resource/pubmed/id/1964212

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-5-2
pubmed:abstractText
Involvement of chloride-dependent, gamma-aminobutyric acid-(GABA-) like synaptic inhibition in the generation of respiratory rhythm was studied in brainstem-spinal cord preparations isolated from newborn rats. Primary respiratory rhythm is presumably generated within the rostral ventrolateral medulla, the site of Pre-I neurones, the firing of which precedes inspiration. Therefore, we examined the responses of Pre-I and inspiratory neurones to GABA antagonists (picrotoxin and bicuculline), a glycine antagonist (strychnine) and reduced chloride concentration in the perfusate. These antagonists (2-20 microM) and reduction of chloride concentration reversibly blocked the transient inhibition of Pre-I activity that occurred during the inspiratory phase. The rhythmic Pre-I and inspiratory neurone activity remained. Changes in the firing properties of Pre-I and inspiratory neurones in 10 microM bicuculline, 10 microM picrotoxin, 5 microM strychnine or reduction of chloride concentration to 40% of normal were analysed statistically. Burst rate of Pre-I neurones tended to increase during these treatments. Delay time from initiation of Pre-I firing to the peak of C4 motorneurone inspiratory activity tended to decrease except during reduced chloride concentration. Changes in mean intraburst firing frequency of Pre-I neurones were not consistent; increase (32%), no change (38%) or decrease (30%). Burst duration of inspiratory neurones decreased. Intraburst firing frequency of inspiratory neurones tended to increase except in 5 microM strychnine. GABA (0.1 mM) or glycine (0.2 mM) reduced the intraburst firing frequency and burst rate of Pre-I neurones, but did not affect the intraburst firing frequency of inspiratory neurones. The burst duration of inspiratory neurones increased during GABA and glycine treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
417
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-32
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Inhibitory synaptic inputs to the respiratory rhythm generator in the medulla isolated from newborn rats.
pubmed:affiliation
Department of Physiology, Showa University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article