Source:http://linkedlifedata.com/resource/pubmed/id/19641882
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2009-7-30
|
| pubmed:abstractText |
We aimed to determine the prevalence of HPV-16/18 antibodies in Korean women with high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer. We conducted the hospital-based case-control study at the university hospital between 2003 and 2006. Cases were 130 high-grade CIN and 43 cervical cancer patients and the control group was 106 women showing normal cervical cytology. Enzyme-linked immunosorbent assays were performed for HPV-16/18 L1 virus-like particles (VLPs) as an antigen. Seropositivity for HPV-16 VLP and HPV-18 VLP was found in 67.4% and 30.2% of cancer patients and 59.2% and 20.0% of high-grade CIN patients, respectively. Seropositivity for HPV-16 with high-grade CIN (OR 6.91; 95% CI 3.74-12.76) and cervical cancer (OR 8.99; 95% CI 3.88-20.84) presented significant associations, as did seropositivity for HPV-18 (high-grade CIN: OR 3.64; 95% CI 1.67-7.95, cervical cancer: OR 6.82; 95% CI 2.52-18.45). Patients with both HPV-16 and 18 seropositivity were 9.38 times (95% CI 2.98-29.51) more likely to have high-grade CIN and 17.05 times (95% CI 4.55-63.87) more likely to have cancer. Both HPV 16 and 18 L1 VLP serology is the clear disease predictors of presence of high-grade CIN and cervical cancer.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0253-6269
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1013-8
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| pubmed:meshHeading |
pubmed-meshheading:19641882-Adult,
pubmed-meshheading:19641882-Aged,
pubmed-meshheading:19641882-Antibodies, Viral,
pubmed-meshheading:19641882-Asian Continental Ancestry Group,
pubmed-meshheading:19641882-Capsid Proteins,
pubmed-meshheading:19641882-Case-Control Studies,
pubmed-meshheading:19641882-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:19641882-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19641882-Female,
pubmed-meshheading:19641882-Human papillomavirus 16,
pubmed-meshheading:19641882-Human papillomavirus 18,
pubmed-meshheading:19641882-Humans,
pubmed-meshheading:19641882-Korea,
pubmed-meshheading:19641882-Middle Aged,
pubmed-meshheading:19641882-Prognosis,
pubmed-meshheading:19641882-Seroepidemiologic Studies,
pubmed-meshheading:19641882-Time Factors,
pubmed-meshheading:19641882-Uterine Cervical Neoplasms,
pubmed-meshheading:19641882-Virion
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Human papillomavirus 16 and 18 L1 serology in Korean women with high-grade cervical intraepithelial neoplasia and cervical cancer.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, College of Medicine, Kyung-Hee University, Seoul, 130-702, Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|