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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2009-8-17
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pubmed:abstractText |
Substituted 8-arylquinoline analogs bearing alkyl-linked side chain were identified as potent inhibitors of type 4 phophodiesterase. These compounds address the potential liabilities of the clinical candidate L-454560. The pharmacokinetic profile of the best analogs and the in vivo efficacy in an ovalbumin-induced bronchoconstriction assay in conscious guinea pigs are reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ChauretNathalieN,
pubmed-author:ClaveauDavidD,
pubmed-author:DayStephenS,
pubmed-author:DeschênesDenisD,
pubmed-author:DubéDanielD,
pubmed-author:GallantMichelM,
pubmed-author:GirardYvesY,
pubmed-author:HuangZhengZ,
pubmed-author:LévesqueJean-FrancoisJF,
pubmed-author:LacombePatrickP,
pubmed-author:LalibertéFranceF,
pubmed-author:LiuSusanaS,
pubmed-author:MacdonaldDwightD,
pubmed-author:ManciniJoseph AJA,
pubmed-author:MassonPaulP,
pubmed-author:NicholsonDonald WDW,
pubmed-author:Nicoll-GriffithDeborah ADA,
pubmed-author:SalemMyriamM,
pubmed-author:StyhlerAngelaA,
pubmed-author:YoungRobert NRN
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5266-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19640717-Animals,
pubmed-meshheading:19640717-Anti-Inflammatory Agents,
pubmed-meshheading:19640717-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19640717-Cyclic Nucleotide Phosphodiesterases, Type 4,
pubmed-meshheading:19640717-Guinea Pigs,
pubmed-meshheading:19640717-Humans,
pubmed-meshheading:19640717-Leukocytes, Mononuclear,
pubmed-meshheading:19640717-Ovalbumin,
pubmed-meshheading:19640717-Phosphodiesterase 4 Inhibitors,
pubmed-meshheading:19640717-Phosphodiesterase Inhibitors,
pubmed-meshheading:19640717-Quinolines,
pubmed-meshheading:19640717-Rats,
pubmed-meshheading:19640717-Saimiri,
pubmed-meshheading:19640717-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
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pubmed:affiliation |
Merck Frosst Center for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada. patrick_lacombe@merck.com
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pubmed:publicationType |
Journal Article
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