| pubmed-article:19639995 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19639995 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:19639995 | lifeskim:mentions | umls-concept:C0118022 | lld:lifeskim |
| pubmed-article:19639995 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:19639995 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19639995 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19639995 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:19639995 | pubmed:dateCreated | 2010-6-21 | lld:pubmed |
| pubmed-article:19639995 | pubmed:abstractText | Following a ligand-based drug design approach, a potent mixed formyl peptide receptor 1 (FPR1) and formyl peptide receptor-like 1 (FPRL1) agonist (14a) and a potent and specific FPRL1 agonist (14x) were identified. These compounds belong to a large series of pyridazin-3(2H)-one derivatives substituted with a methyl group at position 6 and a methoxy benzyl at position 4. At position 2, an acetamide side chain is essential for activity. Likewise, the presence of lipophilic and/or electronegative substituents in the position para to the aryl group at the end of the chain plays a critical role for activity. Affinity for FPR1 receptors was evaluated by measuring intracellular calcium flux in HL-60 cells transfected with FPR1, FPRL1, and FPRL2. Agonists were able to activate intracellular calcium mobilization and chemotaxis in human neutrophils. The most potent chemotactic agent (EC(50) = 0.6 microM) was the mixed FPR/FPRL1 agonist 14h. | lld:pubmed |
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| pubmed-article:19639995 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19639995 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19639995 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19639995 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19639995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19639995 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19639995 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:QuinnMark TMT | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:Dal... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:VergelliClaud... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:YeRichard DRD | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:GiovannoniMar... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:PierettiStefa... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:SchepetkinIgo... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:CesariNicolet... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:GrazianoAless... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:KirpotinaLili... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:BiancalaniCla... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:HoldernessJef... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:CilibrizziAgo... | lld:pubmed |
| pubmed-article:19639995 | pubmed:author | pubmed-author:RabietMarie-J... | lld:pubmed |
| pubmed-article:19639995 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19639995 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:19639995 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19639995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19639995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19639995 | pubmed:pagination | 5044-57 | lld:pubmed |
| pubmed-article:19639995 | pubmed:dateRevised | 2011-1-7 | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:meshHeading | pubmed-meshheading:19639995... | lld:pubmed |
| pubmed-article:19639995 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19639995 | pubmed:articleTitle | 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. | lld:pubmed |
| pubmed-article:19639995 | pubmed:affiliation | Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Firenze, Via Ugo Schiff 6, Sesto Fiorentino 50019 Firenze, Italy. | lld:pubmed |
| pubmed-article:19639995 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19639995 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:19639995 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19639995 | lld:chembl |
