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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-30
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pubmed:abstractText |
Venous leg ulcers are a prevalent nonhealing wound of the lower extremity. Although topically applied growth factors successfully improve wound repair in animal studies, similar studies on humans with venous leg ulcers have not been successful. This study was designed to evaluate the acute safety and biologic feasibility of peri-ulcer injection of a replication-incompetent adenoviral construct expressing platelet-derived growth factor-beta (PDGF-beta). In this phase I study, we demonstrate the initial safety, feasibility, and biologic plausibility of using H5.020CMV.PDGF-beta to treat venous leg ulcer disease.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-01,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-02,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-03,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-04,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-05,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-06,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-07,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-08,
http://linkedlifedata.com/resource/pubmed/grant/K24 AR002212-09,
http://linkedlifedata.com/resource/pubmed/grant/K24AR002212,
http://linkedlifedata.com/resource/pubmed/grant/N01-AR092238,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024134-010001,
http://linkedlifedata.com/resource/pubmed/grant/UL1RR024134
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1525-0024
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1822-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19638959-Adenoviridae,
pubmed-meshheading:19638959-Adult,
pubmed-meshheading:19638959-Cytomegalovirus,
pubmed-meshheading:19638959-Enhancer Elements, Genetic,
pubmed-meshheading:19638959-Female,
pubmed-meshheading:19638959-Gene Therapy,
pubmed-meshheading:19638959-Genetic Vectors,
pubmed-meshheading:19638959-Humans,
pubmed-meshheading:19638959-Leg Ulcer,
pubmed-meshheading:19638959-Male,
pubmed-meshheading:19638959-Middle Aged,
pubmed-meshheading:19638959-Neovascularization, Physiologic,
pubmed-meshheading:19638959-Platelet-Derived Growth Factor,
pubmed-meshheading:19638959-Promoter Regions, Genetic,
pubmed-meshheading:19638959-Treatment Outcome,
pubmed-meshheading:19638959-Varicose Ulcer
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pubmed:year |
2009
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pubmed:articleTitle |
Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease.
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pubmed:affiliation |
Center for Clinical Epidemiology and Biostatistics, 815 Blockley Hall, 423 Guardian Drive, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. margo@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial, Phase I,
Research Support, N.I.H., Extramural
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