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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-26
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pubmed:abstractText |
Thromboembolic events account for significant morbidity and mortality after the Fontan procedure, but the underlying mechanisms remain unclear. P-selectin on platelets indicates platelet activation. Thrombomodulin (TM), a receptor for thrombin and a major anticoagulant proteoglycan on the endothelial membrane, reflects the anticoagulant activity of the endothelium. The present study investigated the hypothesis that the balance between platelet activation and endothelial biological function is impaired in Fontan patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1347-4820
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1705-10
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pubmed:meshHeading |
pubmed-meshheading:19638712-Adolescent,
pubmed-meshheading:19638712-Adult,
pubmed-meshheading:19638712-Antithrombin III,
pubmed-meshheading:19638712-Biological Markers,
pubmed-meshheading:19638712-Blood Coagulation,
pubmed-meshheading:19638712-Blood Platelets,
pubmed-meshheading:19638712-Case-Control Studies,
pubmed-meshheading:19638712-Child,
pubmed-meshheading:19638712-Child, Preschool,
pubmed-meshheading:19638712-Down-Regulation,
pubmed-meshheading:19638712-Endothelium, Vascular,
pubmed-meshheading:19638712-Female,
pubmed-meshheading:19638712-Fontan Procedure,
pubmed-meshheading:19638712-Humans,
pubmed-meshheading:19638712-Male,
pubmed-meshheading:19638712-P-Selectin,
pubmed-meshheading:19638712-Peptide Hydrolases,
pubmed-meshheading:19638712-Platelet Activation,
pubmed-meshheading:19638712-Protein C,
pubmed-meshheading:19638712-Risk Factors,
pubmed-meshheading:19638712-Thromboembolism,
pubmed-meshheading:19638712-Thrombomodulin,
pubmed-meshheading:19638712-Up-Regulation,
pubmed-meshheading:19638712-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patients.
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pubmed:affiliation |
Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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