Linked Life Data

19638256

Source:http://linkedlifedata.com/resource/pubmed/id/19638256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-9-8
pubmed:abstractText
We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1469-5111
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1283-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population.
pubmed:affiliation
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, WA, Australia. dieter.wildenauer@uwa.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't