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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2009-8-28
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pubmed:abstractText |
An efficient and flexible synthesis of poison-frog alkaloids 251O and trans-223B has been achieved by using for both alkaloids an enantiodivergent process starting from the common lactam 1. The relative stereochemistry of 251O and trans-223B was determined to be 7 (R = n-C(7)H(15), R' = n-Pr) and 14 by the present enantioselective synthesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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pubmed:issn |
1520-6904
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6784-91
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:19637860-Alkaloids,
pubmed-meshheading:19637860-Alkenes,
pubmed-meshheading:19637860-Animals,
pubmed-meshheading:19637860-Chemistry, Organic,
pubmed-meshheading:19637860-Chromatography, Gas,
pubmed-meshheading:19637860-Drug Design,
pubmed-meshheading:19637860-Kinetics,
pubmed-meshheading:19637860-Models, Chemical,
pubmed-meshheading:19637860-Poisons,
pubmed-meshheading:19637860-Pyrroles,
pubmed-meshheading:19637860-Pyrrolizidine Alkaloids,
pubmed-meshheading:19637860-Ranidae,
pubmed-meshheading:19637860-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:19637860-Stereoisomerism
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pubmed:year |
2009
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pubmed:articleTitle |
Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B.
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pubmed:affiliation |
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan. toyooka@pha.u-toyama.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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