rdf:type |
|
lifeskim:mentions |
umls-concept:C0024485,
umls-concept:C0031727,
umls-concept:C0037949,
umls-concept:C0231881,
umls-concept:C0439855,
umls-concept:C0935989,
umls-concept:C1514562,
umls-concept:C1516050,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
pubmed:issue |
1
|
pubmed:dateCreated |
2009-7-28
|
pubmed:abstractText |
Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1874-270X
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
41-2
|
pubmed:meshHeading |
pubmed-meshheading:19636920-Amino Acid Sequence,
pubmed-meshheading:19636920-Binding Sites,
pubmed-meshheading:19636920-Carbon Isotopes,
pubmed-meshheading:19636920-Fusion Proteins, bcr-abl,
pubmed-meshheading:19636920-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19636920-Molecular Sequence Data,
pubmed-meshheading:19636920-Molecular Weight,
pubmed-meshheading:19636920-Nitrogen Isotopes,
pubmed-meshheading:19636920-Piperazines,
pubmed-meshheading:19636920-Protein Binding,
pubmed-meshheading:19636920-Protein Kinase Inhibitors,
pubmed-meshheading:19636920-Protons,
pubmed-meshheading:19636920-Pyrimidines
|
pubmed:year |
2008
|
pubmed:articleTitle |
Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib.
|
pubmed:affiliation |
Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|