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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2009-9-9
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pubmed:databankReference |
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pubmed:abstractText |
Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome. Their prognostic significance in adult T-ALL is unclear. We sought to evaluate the outcome according to mutation status of patients with adult T-ALL treated on the United Kingdom Acute Lymphoblastic Leukaemia XII (UKALLXII)/Eastern Cooperative Oncology Group (ECOG) E2993 protocol.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:AllenChristopher GCG,
pubmed-author:BuckGeorginaG,
pubmed-author:DukeVeroniqueV,
pubmed-author:FerrandoAdolfo AAA,
pubmed-author:ForoniLetiziaL,
pubmed-author:GaleRosemary ERE,
pubmed-author:GoldstoneAnthony HAH,
pubmed-author:JenkinsonSarahS,
pubmed-author:KennedyM GMG,
pubmed-author:LinchDavid CDC,
pubmed-author:MansourMarc RMR,
pubmed-author:PaiettaElisabethE,
pubmed-author:RichardsSueS,
pubmed-author:RoweJacob MJM,
pubmed-author:SulisMaria LML,
pubmed-author:TallmanMartin SMS
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4352-6
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19635999-Adolescent,
pubmed-meshheading:19635999-Adult,
pubmed-meshheading:19635999-Cell Cycle Proteins,
pubmed-meshheading:19635999-Chromatography, High Pressure Liquid,
pubmed-meshheading:19635999-DNA Mutational Analysis,
pubmed-meshheading:19635999-Disease-Free Survival,
pubmed-meshheading:19635999-F-Box Proteins,
pubmed-meshheading:19635999-Female,
pubmed-meshheading:19635999-Follow-Up Studies,
pubmed-meshheading:19635999-Gene Frequency,
pubmed-meshheading:19635999-Genotype,
pubmed-meshheading:19635999-Great Britain,
pubmed-meshheading:19635999-Humans,
pubmed-meshheading:19635999-Male,
pubmed-meshheading:19635999-Middle Aged,
pubmed-meshheading:19635999-Multivariate Analysis,
pubmed-meshheading:19635999-Mutation,
pubmed-meshheading:19635999-Precursor T-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19635999-Prognosis,
pubmed-meshheading:19635999-Receptor, Notch1,
pubmed-meshheading:19635999-Treatment Outcome,
pubmed-meshheading:19635999-Ubiquitin-Protein Ligases,
pubmed-meshheading:19635999-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol.
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pubmed:affiliation |
Department of Haematology, University College London, UCL Cancer Institute, WC1E 6BT, United Kingdom. m.mansour@ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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