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rdf:type |
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lifeskim:mentions |
umls-concept:C0021368,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0079189,
umls-concept:C0100748,
umls-concept:C0214743,
umls-concept:C0330390,
umls-concept:C0458827,
umls-concept:C0598934,
umls-concept:C0700624,
umls-concept:C0851285,
umls-concept:C1883220
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-28
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pubmed:abstractText |
Activin A is a member of the TGF-beta superfamily and plays a role in allergic inflammation and asthma pathogenesis. Recent evidence suggests that activin A regulates proinflammatory cytokine production and is regulated by inflammatory mediators. In a murine model of acute allergic airway inflammation, we observed previously that increased activin A concentrations in bronchoalveolar lavage (BAL) fluid coincide with Th2 cytokine production in lung-draining lymph nodes and pronounced mucus metaplasia in bronchial epithelium. We therefore hypothesized that IL-13, the key cytokine for mucus production, regulates activin A secretion into BAL fluid in experimental asthma. IL-13 increased BAL fluid activin A concentrations in naive mice and dose dependently induced activin A secretion from cultured human airway epithelium. A key role for IL-13 in the secretion of activin A into the BAL fluid during allergic airway inflammation was confirmed in IL-13-deficient mice. Eosinophils were not involved in this response because there was no difference in BAL fluid activin A concentrations between wild-type and eosinophil-deficient mice. Our data highlight an important role for IL-13 in the regulation of activin A intraepithelially and in BAL fluid in naive mice and during allergic airway inflammation. Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1535-4989
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pubmed:author |
pubmed-author:DangThanhT,
pubmed-author:HardyCharles LCL,
pubmed-author:LemasurierJeanne SJS,
pubmed-author:MollardRichardR,
pubmed-author:O'HehirRobyn ERE,
pubmed-author:OlssonFredrikF,
pubmed-author:PhillipsDavid JDJ,
pubmed-author:PlebanskiMagdalenaM,
pubmed-author:RodT OTO,
pubmed-author:RollandJennifer MJM,
pubmed-author:YangMingM
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
667-75
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pubmed:meshHeading |
pubmed-meshheading:19635933-Activin Receptors,
pubmed-meshheading:19635933-Activins,
pubmed-meshheading:19635933-Animals,
pubmed-meshheading:19635933-Asthma,
pubmed-meshheading:19635933-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19635933-Cells, Cultured,
pubmed-meshheading:19635933-Disease Models, Animal,
pubmed-meshheading:19635933-Eosinophils,
pubmed-meshheading:19635933-Epithelial Cells,
pubmed-meshheading:19635933-Female,
pubmed-meshheading:19635933-Humans,
pubmed-meshheading:19635933-Inhibin-beta Subunits,
pubmed-meshheading:19635933-Interleukin-13,
pubmed-meshheading:19635933-Interleukin-5,
pubmed-meshheading:19635933-Metaplasia,
pubmed-meshheading:19635933-Mice,
pubmed-meshheading:19635933-Mice, Inbred BALB C,
pubmed-meshheading:19635933-Mice, Knockout,
pubmed-meshheading:19635933-Ovalbumin,
pubmed-meshheading:19635933-Pneumonia,
pubmed-meshheading:19635933-Recombinant Proteins,
pubmed-meshheading:19635933-Respiratory Mucosa,
pubmed-meshheading:19635933-Signal Transduction,
pubmed-meshheading:19635933-Time Factors,
pubmed-meshheading:19635933-Transforming Growth Factor beta
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pubmed:year |
2010
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pubmed:articleTitle |
Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation.
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pubmed:affiliation |
Department of Immunology, Monash University, Commercial Road, Melbourne, VIC 3004 Australia. charles.hardy@med.monash.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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