Linked Life Data

19635622

Source:http://linkedlifedata.com/resource/pubmed/id/19635622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-8-17
pubmed:abstractText
The presented concept combines the widely-established use of macromolecular prodrugs with nanoparticulate drug delivery devices. For this purpose, the water-soluble biopolymer dextran was functionalized with poorly water-soluble drugs (ibuprofen, naproxen) via in situ activation of the carboxylic groups with N,N(')-carbonyldiimidazole (CDI). The resulting hydrophobic derivatives self-assemble into nanoparticles with high loading efficiency during nanoprecipitation. The degree of substitution (DS) and the preparation technique strongly influence the size and the size distribution of the resulting nanoparticles. The particle suspensions remained stable over months in a pH value range between 4 and 11. Derivatives with high DS values are more stable against hydrolysis and after the addition of electrolytes than lowly substituted ones. Therefore, a defined tuning of the DS value may allow the adjustment of the pH-dependent hydrolysis rate and, hence, the release of the drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1095-7103
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
338
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Preparation and characterization of nanoparticles based on dextran-drug conjugates.
pubmed:affiliation
Center of Excellence for Polysaccharide Research, Friedrich-Schiller-Universität Jena, Humboldtstrasse 10, D-07743 Jena, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't