| pubmed-article:19633924 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19633924 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19633924 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
| pubmed-article:19633924 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19633924 | lifeskim:mentions | umls-concept:C1518280 | lld:lifeskim |
| pubmed-article:19633924 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19633924 | pubmed:dateCreated | 2010-3-11 | lld:pubmed |
| pubmed-article:19633924 | pubmed:abstractText | In the present study changes of components of Wnt signaling pathway--axin (AXIN1) and beta-catenin (CTNNB1) in a sample of 72 neuroepithelial brain tumors were investigated. AXIN-1 gene was tested by PCR/loss of heterozygosity (LOH). Immunostaining and image analysis revealed the quantity and localization of relevant proteins. Polymorphic marker for AXIN-1, showed LOH in 11.1% of tumors. LOH was distributed to 6.3% of glioblastomas, one was found in neuroepithelial dysembrioplastic tumor and one in medulloblastoma. Down regulation of axin expression and up regulation of beta-catenin were detected in the analyzed tumors. Axin was observed in the cytoplasm in 68.8% of samples, in 28.1% in both the cytoplasm and nucleus and 3.1% had no expression. Beta-catenin was observed mainly in the nucleus and cytoplasm (59.4%). Expression in 34.4% of samples was in the cytoplasm and 6.3% showed no expression. Comparison of mean values of relative increase of axin and beta-catenin showed that they are significantly reversely proportional (P = 0.014). Relative quantity of beta-catenin in patients with gross deletion of AXIN1 was significantly higher in comparison to patients without LOH (P = 0.040). Our results demonstrate that changes of key components of the Wnt signaling play a role in neuroepithelial brain tumors. | lld:pubmed |
| pubmed-article:19633924 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19633924 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19633924 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19633924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19633924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19633924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19633924 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19633924 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19633924 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19633924 | pubmed:issn | 1532-2807 | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:KusecVesnaV | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:TomasDavorD | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:Pe?ina-SlausN... | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:Nikuseva... | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:ZeljkoMartina... | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:Kokotovi?Tomi... | lld:pubmed |
| pubmed-article:19633924 | pubmed:author | pubmed-author:Musinovi?Hana... | lld:pubmed |
| pubmed-article:19633924 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19633924 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:19633924 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19633924 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19633924 | pubmed:pagination | 75-9 | lld:pubmed |
| pubmed-article:19633924 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
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| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:meshHeading | pubmed-meshheading:19633924... | lld:pubmed |
| pubmed-article:19633924 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19633924 | pubmed:articleTitle | Changes of AXIN-1 and beta-catenin in neuroepithelial brain tumors. | lld:pubmed |
| pubmed-article:19633924 | pubmed:affiliation | Laboratory of Neurooncology, Croatian Institute for Brain Research, School of Medicine University of Zagreb, Salata 12, 10000, Zagreb, Croatia. | lld:pubmed |
| pubmed-article:19633924 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19633924 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| entrez-gene:8312 | entrezgene:pubmed | pubmed-article:19633924 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19633924 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19633924 | lld:entrezgene |
