Source:http://linkedlifedata.com/resource/pubmed/id/19633647
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2009-9-30
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| pubmed:abstractText |
IgG4-associated cholangitis is a steroid-responsive hepatobiliary inflammatory condition associated with autoimmune pancreatitis that clinically and radiologically mimics primary sclerosing cholangitis. In this study, we conducted a morphological and immunohistochemical analysis of liver material obtained from individuals with IgG4-associated cholangitis, and compared these with well-characterized cases of primary sclerosing cholangitis. The study group consisted of 10 patients (9 biopsy and 1 hepatectomy case) with IgG4-associated cholangitis and 17 patients with primary sclerosing cholangitis (16 needle biopsy and 1 hepatectomy case). All patients with IgG4-associated cholangitis had pancreatic involvement as well, and six pancreatectomy samples revealed characteristic histopathological features of autoimmune pancreatitis. Primary sclerosing cholangitis cases were defined by the presence of a characteristic ERCP appearance. Clinical, pathological, radiological, and follow-up data were recorded for all cases. Portal and periportal inflammation was graded according to Ishak's guidelines. Immunohistochemical stains for IgG and IgG4 were performed. The cohort of patients with IgG4-associated cholangitis (mean age: 63 years) was older than individuals with primary sclerosing cholangitis (mean age: 44 years). Seven of these cases showed intrahepatic biliary strictures. IgG4-associated cholangitis liver samples showed higher portal (P=0.06) and lobular (P=0.009) inflammatory scores. Microscopic portal-based fibro-inflammatory nodules that were composed of fibroblasts, plasma cells, lymphocytes, and eosinophils were exclusively observed in five of the IgG4-associated cholangitis cases (50%). More than 10 IgG4-positive plasma cells per HPF (high power field) were observed in 6 of the IgG4-associated cholangitis cases (mean: 60, range: 0-140 per HPF), whereas all primary sclerosing cholangitis cases showed significantly lesser numbers (mean: 0.08, range: 0-1 per HPF). On a liver biopsy, the histological features of IgG4-associated cholangitis may be distinctive, and in conjunction with IgG4 immunohistochemical stain, may help distinguish this disease from primary sclerosing cholangitis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1530-0285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1287-95
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| pubmed:meshHeading |
pubmed-meshheading:19633647-Adult,
pubmed-meshheading:19633647-Aged,
pubmed-meshheading:19633647-Aged, 80 and over,
pubmed-meshheading:19633647-Autoimmune Diseases,
pubmed-meshheading:19633647-Biopsy, Needle,
pubmed-meshheading:19633647-Cholangiopancreatography, Magnetic Resonance,
pubmed-meshheading:19633647-Cholangitis,
pubmed-meshheading:19633647-Cholangitis, Sclerosing,
pubmed-meshheading:19633647-Diagnosis, Differential,
pubmed-meshheading:19633647-Female,
pubmed-meshheading:19633647-Hepatectomy,
pubmed-meshheading:19633647-Humans,
pubmed-meshheading:19633647-Immunoglobulin G,
pubmed-meshheading:19633647-Immunohistochemistry,
pubmed-meshheading:19633647-Immunophenotyping,
pubmed-meshheading:19633647-Liver,
pubmed-meshheading:19633647-Male,
pubmed-meshheading:19633647-Middle Aged,
pubmed-meshheading:19633647-Pancreatitis,
pubmed-meshheading:19633647-Plasma Cells,
pubmed-meshheading:19633647-Predictive Value of Tests,
pubmed-meshheading:19633647-Steroids
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| pubmed:year |
2009
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| pubmed:articleTitle |
IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material.
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| pubmed:affiliation |
The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street,Boston, MA 02114, USA. VDESHPANDE@PARTNERS.ORG
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| pubmed:publicationType |
Journal Article,
Comparative Study
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