Linked Life Data

19632897

Source:http://linkedlifedata.com/resource/pubmed/id/19632897

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-11-3
pubmed:abstractText
Pulmonary delivery of substances in small animal models is often useful for experimental testing of various vaccine and drug candidates. One of the most challenging elements to such protocols is the efficient disposition of test materials in the lungs of mice. Herein we detail a means to deliver dry powders of an inhalant live-attenuated Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine against Mycobacterium tuberculosis to the lungs of mice. The direct delivery methodology is quick, safe, and allows for repeated pulmonary insufflation of substances if boosting is desired. This model system could be easily adapted for use with other dry-powder vaccine and drug candidates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1873-281X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies.
pubmed:affiliation
Department of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't