Source:http://linkedlifedata.com/resource/pubmed/id/19632048
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2009-11-9
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pubmed:abstractText |
ABT-594 is a neuronal nicotinic acetylcholine receptor (NNR) agonist that exhibits potent analgesic activity in preclinical models of acute, chronic, and neuropathic pain. The purpose of this phase 2, randomized, multicenter, double-blind, placebo-controlled study was to evaluate the safety and analgesic efficacy of ABT-594 in patients with diabetic peripheral neuropathic pain (DPNP). A total of 266 DPNP patients were randomized 1:1:1:1 to receive placebo, ABT-594 150 microg BID, ABT-594 225 microg BID, or ABT-594 300 microg BID. Patients were titrated to a fixed-dose of ABT-594 over 7 days and remained at this dose for another 6 weeks. Compared to placebo, all three ABT-594 treatment groups showed significantly greater decreases on the average diary-based 0-10 Pain Rating Scale (PRS) score from baseline to final evaluation, the primary efficacy measure (placebo, -1.1; 150 microg BID, -1.9; 225 microg BID, -1.9; 300 microg BID, -2.0). The proportion of patients achieving at least a 50% improvement in the average diary-based PRS was greater in all three ABT-594 treatment groups. However, adverse event (AE) dropout rates were significantly higher in all three ABT-594 treatment groups (28% for 150 microg BID, 46% for 225 microg BID, and 66% for 300 microg BID) than for the placebo group (9%). Consistent with the expected side-effect profile of NNR agonists, the most frequently reported AEs were nausea, dizziness, vomiting, abnormal dreams, and asthenia. This study establishes proof of concept for NNR agonists as a new class of compounds for treating neuropathic pain.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-(2-azetidinylmethoxy)-2-chloropyri...,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Non-Narcotic,
http://linkedlifedata.com/resource/pubmed/chemical/Azetidines,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1872-6623
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-52
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pubmed:meshHeading |
pubmed-meshheading:19632048-Aged,
pubmed-meshheading:19632048-Analgesics, Non-Narcotic,
pubmed-meshheading:19632048-Azetidines,
pubmed-meshheading:19632048-Data Interpretation, Statistical,
pubmed-meshheading:19632048-Diabetic Neuropathies,
pubmed-meshheading:19632048-Double-Blind Method,
pubmed-meshheading:19632048-Female,
pubmed-meshheading:19632048-Humans,
pubmed-meshheading:19632048-Male,
pubmed-meshheading:19632048-Middle Aged,
pubmed-meshheading:19632048-Nicotinic Agonists,
pubmed-meshheading:19632048-Pain,
pubmed-meshheading:19632048-Pain Measurement,
pubmed-meshheading:19632048-Pyridines,
pubmed-meshheading:19632048-Socioeconomic Factors,
pubmed-meshheading:19632048-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain.
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pubmed:affiliation |
UCSF Pain Clinical Research Center, University of California, San Francisco, CA 94115, USA. Michael.Rowbotham@ucsf.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II
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