Linked Life Data

19631749

Source:http://linkedlifedata.com/resource/pubmed/id/19631749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-9-11
pubmed:abstractText
The neuronal adaptor protein X11alpha/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11alpha in a mouse model of Alzheimer's disease (AD). We crossed hAPPswe/PS-1DeltaE9 transgenic (AD tg) mice with X11alpha heterozygous knockout mice in which X11alpha expression is reduced by approximately 50%. The APP C-terminal fragments C99 and C83, as well as soluble Abeta40 and Abeta42, were increased significantly in brain of X11alpha haploinsufficient mice. Abeta/amyloid plaque burden also increased significantly in the hippocampus and cortex of one year old AD tg/X11alpha (+/-) mice compared to AD tg mice. In contrast, the levels of sAPPalpha and sAPPbeta were not altered significantly in AD tg/X11alpha (+/-) mice. The increased neuropathological indices of AD in mice expressing reduced X11alpha suggest a normal suppressor role for X11alpha on CNS Abeta/amyloid deposition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1095-953X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
162-8
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed-meshheading:19631749-Adaptor Proteins, Signal Transducing, pubmed-meshheading:19631749-Alzheimer Disease, pubmed-meshheading:19631749-Amyloid beta-Peptides, pubmed-meshheading:19631749-Amyloid beta-Protein Precursor, pubmed-meshheading:19631749-Animals, pubmed-meshheading:19631749-Brain, pubmed-meshheading:19631749-Disease Models, Animal, pubmed-meshheading:19631749-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:19631749-Gene Expression Regulation, pubmed-meshheading:19631749-Humans, pubmed-meshheading:19631749-Membrane Proteins, pubmed-meshheading:19631749-Mice, pubmed-meshheading:19631749-Mice, Inbred C57BL, pubmed-meshheading:19631749-Mice, Transgenic, pubmed-meshheading:19631749-Mutation, pubmed-meshheading:19631749-Peptide Fragments, pubmed-meshheading:19631749-Presenilin-1
pubmed:year
2009
pubmed:articleTitle
X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.
pubmed:affiliation
Department of Neurology, University of Michigan, USA. isaluja@med.umich.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural