Linked Life Data

19631373

Source:http://linkedlifedata.com/resource/pubmed/id/19631373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
29
pubmed:dateCreated
2009-8-18
pubmed:abstractText
A series of well-defined, fluorescently labelled homopolymers, random and block copolymers based on N-(2-hydroxypropyl)-methacrylamide were prepared by reversible addition-fragmentation chain transfer polymerization (RAFT polymerization). The polydispersity indexes for all polymers were in the range of 1.2-1.3 and the number average of the molar mass (M(n)) for each polymer was set to be in the range of 15-30 kDa. The cellular uptake of these polymers was investigated in the human multi-drug resistant breast adenocarcinoma cell line MCF7/ADR. The uptake greatly depended on the polymer molecular mass and structure. Specifically, smaller polymers (approx. 15 kDa) were taken up by the cells at much lower concentrations than larger polymers (approx. 30 kDa). Furthermore, for polymers of the same molar mass, the random copolymers were more easily internalized in cells than block copolymers or homopolymers. This is attributed to the fact that random copolymers form micelle-like aggregates by intra- and interchain interactions, which are smaller and less stable than the block copolymer structures in which the hydrophobic domain is buried and thus prevented from unspecific interaction with the cell membrane. Our findings underline the need for highly defined polymeric carriers and excipients for future applications in the field of nanomedicine.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-10840193, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-11749397, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-12538842, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-14531722, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-15738981, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-16900224, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-17530906, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-18500347, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-18592353, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-18654486, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-18697944, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-18855476, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-2946403, http://linkedlifedata.com/resource/pubmed/commentcorrection/19631373-6178742
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1878-5905
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5682-90
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells.
pubmed:affiliation
Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural