Linked Life Data

19631255

Source:http://linkedlifedata.com/resource/pubmed/id/19631255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-8-11
pubmed:abstractText
Many neuropsychological studies have shown that the Digit Symbol Test (DST) of the Wechsler Adult Intelligence Scale (WAIS) is useful for screening for dysfunctions of the brain. However, it remains unclear which brain areas are actually involved in the performance of DST and what brain functions are used for executing this test. In this study, we examined the cortical areas related to cognitive aspects of DST using functional magnetic resonance imaging (fMRI) and determined executive brain functions involved in this test on the basis of fMRI results. Eleven healthy young adults (mean=21.6 years) performed a modified DST (mDST) task and its control task, which required a simple graphomotor response during fMRI data acquisition. The direct comparison of brain activations between the mDST task and the control task revealed greater activations in a fronto-parietal cortical network, including the bilateral inferior frontal sulci, left middle frontal gyrus (close to the frontal eye field) and left posterior parietal cortex. These activations are interpreted as reflecting the visual search process and/or the updating process of working memory during the mDST task execution. Furthermore, we found a positive correlation between the number of correct responses and activations in the bilateral inferior frontal regions, suggesting that these prefrontal areas have a crucial role in the performance of DST in a healthy young adult population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1872-7972
pubmed:author
pubmed:issnType
Electronic
pubmed:day
29
pubmed:volume
463
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cortical areas related to performance of WAIS Digit Symbol Test: a functional imaging study.
pubmed:affiliation
Division of Applied System Neuroscience, Department of Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't