Linked Life Data

19629630

Source:http://linkedlifedata.com/resource/pubmed/id/19629630

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-8-24
pubmed:abstractText
Chronic lymphocytic leukemia (CLL) shows a remarkable heterogeneity, with some patients having an almost normal lifespan, others surviving only several months after diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CLL and its correlation with well-established other prognostic factors. Enhanced chemiluminescent dot blot assay was performed to measure serum TK1 concentration in 80 CLL patients. The concentration of TK1 was significantly increased in patients with Binet C (P = 0.002), higher levels of serum lactate dehydrogenase (LDH) (P = 0.012) and beta2-microglobulin (beta2-MG) (P = 0.025), unmutated IGHV status (P < 0.001), or higher expression levels of ZAP-70 (P = 0.014) and CD38 (P = 0.018) groups compared to the patients with Binet A, lower levels of serum LDH and beta2-MG, mutated IGHV status, or lower expression levels of ZAP-70 and CD38 groups, respectively. Strong correlation of TK1 level with IGHV mutations (r = 0.412, P < 0.001) or ZAP-70 (r = 0.263, P = 0.024) was observed. According to receiver operating characteristic curve analysis for serum TK1 concentration and IGHV mutational status, area under the curve was 0.757 (P = 0.001) and the optimal cut-off value of serum TK1 concentration level was 1.75 pM, with a 87.8% specificity, a 63.6% sensitivity. It was showed that serum TK1 concentration could be a predictive marker of IGHV mutational status, and might be applied for the assessment of prognosis in patients with CLL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1865-3774
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-11
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19629630-Adult, pubmed-meshheading:19629630-Aged, pubmed-meshheading:19629630-Aged, 80 and over, pubmed-meshheading:19629630-Antigens, CD38, pubmed-meshheading:19629630-Asian Continental Ancestry Group, pubmed-meshheading:19629630-Biological Markers, pubmed-meshheading:19629630-Female, pubmed-meshheading:19629630-Humans, pubmed-meshheading:19629630-Immunoglobulin Heavy Chains, pubmed-meshheading:19629630-L-Lactate Dehydrogenase, pubmed-meshheading:19629630-Leukemia, Lymphocytic, Chronic, B-Cell, pubmed-meshheading:19629630-Male, pubmed-meshheading:19629630-Middle Aged, pubmed-meshheading:19629630-Mutation, pubmed-meshheading:19629630-Predictive Value of Tests, pubmed-meshheading:19629630-Prognosis, pubmed-meshheading:19629630-ROC Curve, pubmed-meshheading:19629630-Thymidine Kinase, pubmed-meshheading:19629630-ZAP-70 Protein-Tyrosine Kinase, pubmed-meshheading:19629630-beta 2-Microglobulin
pubmed:year
2009
pubmed:articleTitle
Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors.
pubmed:affiliation
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't