| pubmed-article:19628771 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0682323 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0009404 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C1833235 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19628771 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19628771 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19628771 | pubmed:dateCreated | 2009-7-27 | lld:pubmed |
| pubmed-article:19628771 | pubmed:abstractText | Death-associated protein kinase (DAPK) is a serine/threonine kinase that contributes to pro-apoptotic signaling on cytokine exposure. The role of DAPK in macrophage-associated tumor cell death is currently unknown. Recently, we suggested a new function for DAPK in the induction of apoptosis during the interaction between colorectal tumor cells and tumor-associated macrophages. Using a cell-culture model with conditioned supernatants of differentiated/activated macrophages (U937) and human HCT116 colorectal tumor cells, we replicated DAPK-associated tumor cell death; this model likely reflects the in vivo tumor setting. In this study, we show that tumor necrosis factor-alpha exposure under conditions of macrophage activation induced DAPK-dependent apoptosis in the colorectal tumor cell line HCT116. Simultaneously, early phosphorylation of p38 mitogen-activated protein kinase (phospho-p38) was observed. We identified the phospho-p38 mitogen-activated protein kinase as a novel interacting protein of DAPK in tumor necrosis factor-alpha-induced apoptosis. The general relevance of this interaction was verified in two colorectal cell lines without functional p53 (ie, HCT116 p53(-/-) and HT29 mutant) and in human colon cancer and ulcerative colitis tissues. Supernatants of freshly isolated human macrophages were also able to induce DAPK and phospho-p38. Our findings highlight the mechanisms that underlie DAPK regulation in tumor cell death evoked by immune cells. | lld:pubmed |
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| pubmed-article:19628771 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19628771 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19628771 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19628771 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19628771 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19628771 | pubmed:issn | 1525-2191 | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:LeverkusMarti... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:RoessnerAlber... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:BommhardtUrsu... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:Schneider-Sto... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:HartigRolandR | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:KlicheStefani... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:KuesterDoerth... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:DrewesThomasT | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:BajboujKhulou... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:WalluscheckDi... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:PoehlmannAnge... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:HaaseKathrinK | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:TellerAnneA | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:IvanovskaJele... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:ChakilamSarit... | lld:pubmed |
| pubmed-article:19628771 | pubmed:author | pubmed-author:UlitzschAnnik... | lld:pubmed |
| pubmed-article:19628771 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19628771 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:19628771 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19628771 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19628771 | pubmed:pagination | 557-70 | lld:pubmed |
| pubmed-article:19628771 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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| pubmed-article:19628771 | pubmed:meshHeading | pubmed-meshheading:19628771... | lld:pubmed |
| pubmed-article:19628771 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19628771 | pubmed:articleTitle | Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells. | lld:pubmed |
| pubmed-article:19628771 | pubmed:affiliation | Experimental Tumor Pathology, Institute of Pathology, University of Erlangen-Nuremberg, Universitätsstr. 22, 91054 Erlangen, Germany. | lld:pubmed |
| pubmed-article:19628771 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19628771 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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