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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-2
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pubmed:abstractText |
X-linked inhibitor of apoptosis-associated factor 1 (XAF1) was first recognized as an antagonist of X-linked inhibitor of apoptosis in suppressing caspase 3 activity. It has lower expression in cancer cells than normal tissue. Overexpression of XAF1 can inhibit cancer cell growth and sensitize tumor necrosis factor-related apoptosis-inducing ligand- or etoposide-induced apoptosis. The aim of this study is to elucidate the mechanism of XAF1 in regulating cell growth.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1460-2180
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pubmed:author |
pubmed-author:CaseN BNB,
pubmed-author:ChanShingS,
pubmed-author:HungIvan FIF,
pubmed-author:JiangBoB,
pubmed-author:LanHui YaoHY,
pubmed-author:LiMingM,
pubmed-author:MaJuanJ,
pubmed-author:QiaoLiangL,
pubmed-author:RIBIAA,
pubmed-author:TuShuipingS,
pubmed-author:WangJideJ,
pubmed-author:WongBenjamin C YBC,
pubmed-author:YangMoM,
pubmed-author:ZhangWenjingW
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1507-16
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19628579-Apoptosis,
pubmed-meshheading:19628579-Caspase 3,
pubmed-meshheading:19628579-Cell Cycle,
pubmed-meshheading:19628579-Cell Division,
pubmed-meshheading:19628579-Cell Line,
pubmed-meshheading:19628579-Cell Proliferation,
pubmed-meshheading:19628579-Cyclin B,
pubmed-meshheading:19628579-DNA Damage,
pubmed-meshheading:19628579-G2 Phase,
pubmed-meshheading:19628579-Gastrointestinal Neoplasms,
pubmed-meshheading:19628579-Humans,
pubmed-meshheading:19628579-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:19628579-Mitosis,
pubmed-meshheading:19628579-Neoplasm Proteins,
pubmed-meshheading:19628579-Protein Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Identification of XAF1 as a novel cell cycle regulator through modulating G(2)/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer.
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pubmed:affiliation |
Department of Digestive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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