Linked Life Data

19628023

Source:http://linkedlifedata.com/resource/pubmed/id/19628023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-10-12
pubmed:abstractText
The recent characterization of excitatory and inhibitory synaptic receptive fields in rat auditory cortex laid the basis for further investigation of the roles of synaptic excitation and inhibition in cortical computation and plasticity. The mouse is an increasingly important model system because of the wide range of genetic tools available for it. Here we present the first in vivo whole-cell voltage-clamp measurements of synaptic excitation and inhibition in the mouse cortex. We find that a substantial population of auditory cortical neurons receives balanced synaptic excitation and inhibition, whose amplitude ratios and relative time courses remain approximately constant across tone frequency. We conclude that the synaptic mechanisms underlying tone-evoked auditory cortical responses in mice closely resemble those in rats, supporting the mouse as a suitable model for synaptic processing in auditory cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1873-7544
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1302-15
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Balanced tone-evoked synaptic excitation and inhibition in mouse auditory cortex.
pubmed:affiliation
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
pubmed:publicationType
Journal Article