Linked Life Data

19627765

Source:http://linkedlifedata.com/resource/pubmed/id/19627765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-7-24
pubmed:abstractText
Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms but their incidence has significantly increased in the last 30 years. These tumors are usually sporadic but can also occur as part of certain endocrine tumor susceptibility syndromes such as multiple endocrine neoplasia type1 (MEN1) and von Hippel Lindau disease. The genetic abnormalities associated with the development or progression of these tumors depend on the site of origin and suggest multiple gene involvement. Knowledge of this genetic complex has been gained from a variety of approaches such as comparative genomic hybridization, loss of heterozygosity and DNA microarray analysis. These genetic studies indicate that pancreatic endocrine tumors frequently harbor mutations in the MEN1 gene, among others, and that carcinoid tumors, in contrast, show more alterations on chromosome 18. Nevertheless, the molecular pathogenesis of gastroenteropancreatic neuroendocrine tumors remains to be fully elucidated, mainly because the data refer to small and heterogeneous tumor series.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1579-2021
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
56 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Genetic profile of gastroenteropancreatic neuroendocrine tumors].
pubmed:affiliation
Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Santiago (C.H.U.S.), Santiago de Compostela, España. jose.manuel.cabezas.agricola@sergas.es
pubmed:publicationType
Journal Article, English Abstract